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In patients with creatinine clearance 30 – 50 mL/min, start dosing at 25 mg once daily, and increase the dose to 5 mg once daily based upon individual response [see Dosage and Administration ( 26), Use in Specific Populations ( 87), and Clinical Pharmacology ( 123)]. If you might be interested feel free to send me an e-mail.
There was, however, a significantly increased rate of renal dysfunction associated with combination therapy (135%) compared to ramipril (102%) or telmisartan (106%) alone and a significantly increased rate of hyperkalemia with combination therapy compared to ramipril (56% vs.
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